Lithium Hydroxide → 3-Chloro-4-(piperidin-2-on-1-yl)-benzoic acid

HRID 551189Notes

Reaction equation

HRID 551189 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:9]=[CH:10][C:11]=1[N:12]1[CH2:17][CH2:16][CH2:15][CH2:14][C:13]1=[O:18])[C:5]([O:7]C)=[O:6].[OH-].[Li+]>C(O)C>[Cl:1][C:2]1[CH:3]=[C:4]([CH:9]=[CH:10][C:11]=1[N:12]1[CH2:17][CH2:16][CH2:15][CH2:14][C:13]1=[O:18])[C:5]([OH:7])=[O:6]

Participants

4

Reactant 2

HCID 3939Lithium HydroxideHCID 67048141Methyl 3-chloro-4-(piperidin-2-on-1-yl)-benzoate

Product 1

HCID 643174403-Chloro-4-(piperidin-2-on-1-yl)-benzoic acid

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Prepared analogously to Example 39d from methyl 3-chloro-4-(piperidin-2-on-1-yl)-benzoate and 8% lithium hydroxide solution in ethanol.

Sources & evidence

ORD record
ord-e2251e93b8c14fecb1f92b0d53338e43
Source dataset
uspto-grants-2011_05
Patent number
US07947700B2

Reaction notes

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