HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(Trifluoromethyl)phenol → 4-Cyano-2-(3-thienylmethyloxy)-6-(meta-trifluoromethylphenoxy)pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(Trifluoromethyl)phenol | HCID 7376 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2-Chloro-4-cyano-6-(3-thienylmethyloxy)pyridine | HCID 19957389 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | 4-Cyano-2-(3-thienylmethyloxy)-6-(meta-trifluoromethylphenoxy)pyridine | HCID 19957406 | — |
Reaction Steps
2-Chloro-4-cyano-6-(3-thienylmethyloxy)pyridine (0.79 g, 0.00315 mol) and meta-trifluoromethylphenol (0.57 g, 0.00315×1.1 mol) were dissolved in 20 ml of N-methyl-2-pyrrolidinone, and anhydrous potassium carbonate (0.48 g, 0.00315×1.1 mol) was added thereto, and the resultant solution was stirred for about 4 hours at about 100° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05624942 |
| Source dataset | uspto-grants-1997_04 |
| ORD ID | ord-2dae92a9d2e944368d0159af6b9fca27 |
| Source note | uspto-grants-1997_04 |