3-(Trifluoromethyl)phenol → 4-Cyano-2-(3-thienylmethyloxy)-6-(meta-trifluoromethylphenoxy)pyridine
Reaction equation
Cl[C:2]1[CH:7]=[C:6]([C:8]#[N:9])[CH:5]=[C:4]([O:10][CH2:11][C:12]2[CH:16]=[CH:15][S:14][CH:13]=2)[N:3]=1.[F:17][C:18]([F:27])([F:26])[C:19]1[CH:20]=[C:21]([OH:25])[CH:22]=[CH:23][CH:24]=1.C(=O)([O-])[O-].[K+].[K+]>CN1CCCC1=O>[C:8]([C:6]1[CH:7]=[C:2]([O:25][C:21]2[CH:22]=[CH:23][CH:24]=[C:19]([C:18]([F:17])([F:26])[F:27])[CH:20]=2)[N:3]=[C:4]([O:10][CH2:11][C:12]2[CH:16]=[CH:15][S:14][CH:13]=2)[CH:5]=1)#[N:9]Participants
5
Procedure
2-Chloro-4-cyano-6-(3-thienylmethyloxy)pyridine (0.79 g, 0.00315 mol) and meta-trifluoromethylphenol (0.57 g, 0.00315×1.1 mol) were dissolved in 20 ml of N-methyl-2-pyrrolidinone, and anhydrous potassium carbonate (0.48 g, 0.00315×1.1 mol) was added thereto, and the resultant solution was stirred for about 4 hours at about 100° C.
Sources & evidence
- ORD record
- ord-2dae92a9d2e944368d0159af6b9fca27
- Source dataset
- uspto-grants-1997_04
- Patent number
- US05624942
Reaction notes
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