Dimethylformamide → 3-Fluoro-4-(morpholin-3-on-4-yl)benzoic acid-chloride
Reaction equation
[C:1]([CH2:4][O:5][CH2:6][CH2:7][NH:8][C:9]1[CH:17]=[CH:16][C:12]([C:13](O)=[O:14])=[CH:11][C:10]=1[F:18])(O)=[O:2].S(Cl)([Cl:21])=O.CN(C=O)C>ClCCl>[F:18][C:10]1[CH:11]=[C:12]([CH:16]=[CH:17][C:9]=1[N:8]1[CH2:7][CH2:6][O:5][CH2:4][C:1]1=[O:2])[C:13]([Cl:21])=[O:14]Participants
5
Procedure
Prepared analogously to Example 41c from 4-(2-carboxymethoxy-ethylamino)-3-fluoro-benzoic acid and thionylchloride in dichloromethane with DMF.
Sources & evidence
- ORD record
- ord-eff8ed3daecc40ec8700d344e07f67f0
- Source dataset
- uspto-grants-2011_05
- Patent number
- US07947700B2
Reaction notes
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