HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(Trifluoromethyl)phenol → 4-Methylmercapto-2-(3-thienylmethyloxy)-6-(meta-trifluoromethylphenoxy)pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(Trifluoromethyl)phenol | HCID 7376 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 2-Chloro-4-methylmercapto-6-(3-thienylmethyloxy)pyridine | HCID 53958130 | — |
| Catalyst | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 4-Methylmercapto-2-(3-thienylmethyloxy)-6-(meta-trifluoromethylphenoxy)pyridine | HCID 54481631 | — |
Reaction Steps
To a solution containing meta-trifluoromethylphenol (1.60 g, 0.0024×4.1 mol), sodium hydride (0.29 g, (ca.60% in mineral oil), 0.0024×3.0 mol) and CuI (0.22 g, 0.0024×0.5 mol) in dimethylformamide, 2-chloro-4-methylmercapto-6-(3-thienylmethyloxy)pyridine (0.64 g, 0. 0024 mol) was added and the resultant solution was refluxed for about 6 hours.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05624942 |
| Source dataset | uspto-grants-1997_04 |
| ORD ID | ord-f9a20e6ae4d141f68ece0b6e8353fb8d |
| Source note | uspto-grants-1997_04 |