反应详情

In a solution of 0.40 g of N-[1-[2-chloro-4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]phenyl]ethyl]phthalimide in 10 mL of ethanol, 1.0 mL of 80% hydrazine monohydrate aqueous solution was added, and stirred under reflux with heating for 1 hour. After the completion of the reaction, the reaction mixture was left and cooled to room temperature, 20 mL of chloroform was added therein and insoluble substance was filtered off, and the solvent was distilled off under reduced pressure. The procedure comprising adding 20 mL of chloroform in the residue, filtering off insoluble material and distilling off the solvent under reduced pressure was repeated twice to obtain 0.26 g of the aimed product as yellow resinous substance.

1. temperatureunder reflux
2. temperaturewith heating for 1 hour
3. customAfter the completion of the reaction
4. waitthe reaction mixture was left
5. filtrationinsoluble substance was filtered off
6. distillationthe solvent was distilled off under reduced pressure
7. additionThe procedure comprising adding 20 mL of chloroform in the residue
8. filtrationfiltering off insoluble material
9. distillationdistilling off the solvent under reduced pressure