4-Piperidinol, 1-methyl- → Oxo-thiophen-2-yl-acetic acid 1-methyl-piperidin-4-yl ester

Participants

Reaction Steps

To a solution of oxo-thiophen-2-yl-acetyl chloride (29 mmol) at 0 to 5° C. in chloroform (60 ml) is added a solution of 1-methyl-piperidine-4-ol (5.87 g, 29 mmol) in chloroform (60 ml), dropwise with stirring. The resulting mixture is stirred for 2 hours at room temperature. Washing with 10% potassium carbonate solution, water (×2), drying over magnesium sulphate, filtration and evaporation gives the title compound.

Provenance & Evidence