反应详情

To a solution of oxo-thiophen-2-yl-acetyl chloride (29 mmol) at 0 to 5° C. in chloroform (60 ml) is added a solution of 1-methyl-piperidine-4-ol (5.87 g, 29 mmol) in chloroform (60 ml), dropwise with stirring. The resulting mixture is stirred for 2 hours at room temperature. Washing with 10% potassium carbonate solution, water (×2), drying over magnesium sulphate, filtration and evaporation gives the title compound.

1. stirringThe resulting mixture is stirred for 2 hours at room temperature
2. washWashing with 10% potassium carbonate solution, water (×2)
3. dry with materialdrying over magnesium sulphate, filtration and evaporation