Ethylamine → 3-(Ethylamino)-1,1,1-trifluoro-2-{[(1-phenyl-1H-indazol-4-yl)amino]methyl}-2-propanol

HRID 551428Notes

Reaction equation

HRID 551428 reaction equation
[C:1]1([N:7]2[C:15]3[CH:14]=[CH:13][CH:12]=[C:11]([NH:16][CH2:17][C:18]4([C:21]([F:24])([F:23])[F:22])[CH2:20][O:19]4)[C:10]=3[CH:9]=[N:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH2:25]([NH2:27])[CH3:26]>O1CCCC1>[CH2:25]([NH:27][CH2:20][C:18]([CH2:17][NH:16][C:11]1[CH:12]=[CH:13][CH:14]=[C:15]2[C:10]=1[CH:9]=[N:8][N:7]2[C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1)([OH:19])[C:21]([F:24])([F:23])[F:22])[CH3:26]

Participants

4

Reactant 2

HCID 6341EthylamineHCID 249380531-Phenyl-N-{[2-(trifluoromethyl)-2-oxiranyl]methyl}-1H-indazol-4-amine

Product 1

HCID 593241573-(Ethylamino)-1,1,1-trifluoro-2-{[(1-phenyl-1H-indazol-4-yl)amino]methyl}-2-propanol

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a solution of 1-phenyl-N-{[2-(trifluoromethyl)-2-oxiranyl]methyl}-1H-indazol-4-amine (1.235 g, 3.7 mmol) in anhydrous tetrahydrofuran (5 ml) was added ethylamine (2M in tetrahydrofuran) (10 ml, 20 mmol). The reaction was stirred at room temperature for approximately 72 hours and then evaporated in vacuo to give the title compound.

Workup

  1. customevaporated in vacuo

Sources & evidence

ORD record
ord-0b4b2774ad004c15abf2e7cbc7523362
Source dataset
uspto-grants-2011_05
Patent number
US07947727B2

Reaction notes

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