Ethylamine → 3-(Ethylamino)-1,1,1-trifluoro-2-{[(6-methyl-1-phenyl-1H-indazol-4-yl)amino]methyl}-2-propanol

HRID 551431Notes

Reaction equation

HRID 551431 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]([NH:17][CH2:18][C:19]2([C:22]([F:25])([F:24])[F:23])[CH2:21][O:20]2)[C:5]2[CH:6]=[N:7][N:8]([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=3)[C:9]=2[CH:10]=1.[CH2:26]([NH2:28])[CH3:27]>O1CCCC1>[CH2:26]([NH:28][CH2:21][C:19]([CH2:18][NH:17][C:4]1[CH:3]=[C:2]([CH3:1])[CH:10]=[C:9]2[C:5]=1[CH:6]=[N:7][N:8]2[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)([OH:20])[C:22]([F:24])([F:23])[F:25])[CH3:27]

Participants

4

Reactant 2

HCID 6341EthylamineHCID 249380556-Methyl-1-phenyl-N-{[2-(trifluoromethyl)-2-oxiranyl]methyl}-1H-indazol-4-amine

Product 1

HCID 593241363-(Ethylamino)-1,1,1-trifluoro-2-{[(6-methyl-1-phenyl-1H-indazol-4-yl)amino]methyl}-2-propanolYield 102.9%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a solution of 6-methyl-1-phenyl-N-{[2-(trifluoromethyl)-2-oxiranyl]methyl}-1H-indazol-4-amine (1.1 g, 3.17 mmol) in anhydrous tetrahydrofuran (5 ml) was added ethylamine (2M in tetrahydrofuran) (10 ml, 20 mmol). The reaction was stirred at room temperature for 6 hours and then evaporated in vacuo to give the title compound (1.28 g).

Workup

  1. customevaporated in vacuo

Sources & evidence

ORD record
ord-0f23ca23095f420d937cfeeb08c1032f
Source dataset
uspto-grants-2011_05
Patent number
US07947727B2

Reaction notes

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