Thiophene-3-carboxylic acid → HCID 59324139, compound

HRID 551448Notes

Reaction equation

HRID 551448 reaction equation
[S:1]1[CH:5]=[CH:4][C:3]([C:6]([OH:8])=O)=[CH:2]1.[CH2:9]([NH:11][CH2:12][C:13]([CH2:19][NH:20][C:21]1[CH:29]=[C:28]([CH3:30])[CH:27]=[C:26]2[C:22]=1[CH:23]=[N:24][N:25]2[C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1)([OH:18])[C:14]([F:17])([F:16])[F:15])[CH3:10]>>[CH2:9]([N:11]([CH2:12][C:13]([OH:18])([CH2:19][NH:20][C:21]1[CH:29]=[C:28]([CH3:30])[CH:27]=[C:26]2[C:22]=1[CH:23]=[N:24][N:25]2[C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1)[C:14]([F:17])([F:16])[F:15])[C:6]([C:3]1[CH:4]=[CH:5][S:1][CH:2]=1)=[O:8])[CH3:10]

Participants

3

Reactant 2

HCID 6918Thiophene-3-carboxylic acidHCID 593241363-(Ethylamino)-1,1,1-trifluoro-2-{[(6-methyl-1-phenyl-1H-indazol-4-yl)amino]methyl}-2-propanol

Product 1

HCID 59324139HCID 59324139, compound

Procedure

Prepared similarly to Example 11 from 3-thiophenecarboxylic acid and 3-(ethylamino)-1,1,1-trifluoro-2-{[(6-methyl-1-phenyl-1H-indazol-4-yl)amino]methyl}-2-propanol.

Sources & evidence

ORD record
ord-b61292cdff81421ca96042c026772f4c
Source dataset
uspto-grants-2011_05
Patent number
US07947727B2

Reaction notes

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