Thiophene-3-carboxylic acid → HCID 59324155, compound

HRID 551461Notes

Reaction equation

HRID 551461 reaction equation
[S:1]1[CH:5]=[CH:4][C:3]([C:6]([OH:8])=O)=[CH:2]1.[F:9][C:10]([F:38])([F:37])[C:11]([CH2:32][NH:33][CH2:34][CH2:35][CH3:36])([OH:31])[CH2:12][NH:13][C:14]1[CH:22]=[C:21]([CH3:23])[CH:20]=[C:19]2[C:15]=1[CH:16]=[N:17][N:18]2[C:24]1[CH:29]=[CH:28][C:27]([F:30])=[CH:26][CH:25]=1>>[CH2:34]([N:33]([CH2:32][C:11]([CH2:12][NH:13][C:14]1[CH:22]=[C:21]([CH3:23])[CH:20]=[C:19]2[C:15]=1[CH:16]=[N:17][N:18]2[C:24]1[CH:25]=[CH:26][C:27]([F:30])=[CH:28][CH:29]=1)([OH:31])[C:10]([F:9])([F:37])[F:38])[C:6]([C:3]1[CH:4]=[CH:5][S:1][CH:2]=1)=[O:8])[CH2:35][CH3:36]

Participants

3

Reactant 2

HCID 6918Thiophene-3-carboxylic acidHCID 593241651,1,1-Trifluoro-3-{[1-(4-fluorophenyl)-6-methyl-1H-indazol-4-yl]amino}-2-[(propylamino)methyl]-2-propanol

Product 1

HCID 59324155HCID 59324155, compound

Procedure

Prepared similarly to Example 1 from 3-thiophenecarboxylic acid and 1,1,1-trifluoro-3-{[1-(4-fluorophenyl)-6-methyl-1H-indazol-4-yl]amino}-2-[(propylamino)methyl]-2-propanol.

Sources & evidence

ORD record
ord-53149bdcc8ab496ea9193f021bed960a
Source dataset
uspto-grants-2011_05
Patent number
US07947727B2

Reaction notes

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