2-Thiophenecarboxylic acid → N-Ethyl-N-(3,3,3-trifluoro-2-hydroxy-2-{[(1-phenyl-1H-indazol-4-yl)amino]methyl}propyl)-2-thiophenecarboxamide

HRID 551464Notes

Reaction equation

HRID 551464 reaction equation
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]([OH:8])=O.[CH2:9]([NH:11][CH2:12][C:13]([CH2:19][NH:20][C:21]1[CH:29]=[CH:28][CH:27]=[C:26]2[C:22]=1[CH:23]=[N:24][N:25]2[C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1)([OH:18])[C:14]([F:17])([F:16])[F:15])[CH3:10]>>[CH2:9]([N:11]([CH2:12][C:13]([OH:18])([CH2:19][NH:20][C:21]1[CH:29]=[CH:28][CH:27]=[C:26]2[C:22]=1[CH:23]=[N:24][N:25]2[C:30]1[CH:31]=[CH:32][CH:33]=[CH:34][CH:35]=1)[C:14]([F:17])([F:16])[F:15])[C:6]([C:2]1[S:1][CH:5]=[CH:4][CH:3]=1)=[O:8])[CH3:10]

Participants

3

Reactant 2

HCID 107002-Thiophenecarboxylic acidHCID 593241573-(Ethylamino)-1,1,1-trifluoro-2-{[(1-phenyl-1H-indazol-4-yl)amino]methyl}-2-propanol

Product 1

HCID 59324144N-Ethyl-N-(3,3,3-trifluoro-2-hydroxy-2-{[(1-phenyl-1H-indazol-4-yl)amino]methyl}propyl)-2-thiophenecarboxamide

Procedure

Prepared similarly to Example 1 from 2-thiophenecarboxylic acid and 3-(Ethylamino)-1,1,1-trifluoro-2-{[(1-phenyl-1H-indazol-4-yl)amino]methyl}-2-propanol.

Sources & evidence

ORD record
ord-63510c9689e042b7b128710c0f9b922c
Source dataset
uspto-grants-2011_05
Patent number
US07947727B2

Reaction notes

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