HRID551489

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID145458

2-Fluoro-6-(trifluoromethyl)benzoyl chloride

C8H3ClF4O

结构：CCCNCC(O)(CNc1cccc2c1cnn2-c1ccc(F)cc1)C(F)(F)F

HCID59324137

未命名化合物

PRODUCTS

生成物

结构：CCN(CC(O)(CNc1cccc2c1cnn2-c1ccc(F)cc1)C(F)(F)F)C(=O)c1c(F)cccc1C(F)(F)F

HCID59324135

未命名化合物

PROCEDURE

实验过程

Prepared similarly to Example 48 from 2-fluoro-6-(trifluoromethyl)benzoyl chloride and 1,1,1-trifluoro-3-{[1-(4-fluorophenyl)-1H-indazol-4-yl]amino}-2-[(propylamino)methyl]-2-propanol.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-aa2770bcfa144d55b21d0108cd326fb3
来源数据集: uspto-grants-2011_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07947727B2
来源说明: uspto-grants-2011_05

反应 SMILES

[F:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]([C:11]([F:14])([F:13])[F:12])[C:3]=1[C:4](Cl)=[O:5].[F:15][C:16]([F:43])([F:42])[C:17]([CH2:37][NH:38][CH2:39][CH2:40]C)([OH:36])[CH2:18][NH:19][C:20]1[CH:28]=[CH:27][CH:26]=[C:25]2[C:21]=1[CH:22]=[N:23][N:24]2[C:29]1[CH:34]=[CH:33][C:32]([F:35])=[CH:31][CH:30]=1>>[CH2:39]([N:38]([CH2:37][C:17]([CH2:18][NH:19][C:20]1[CH:28]=[CH:27][CH:26]=[C:25]2[C:21]=1[CH:22]=[N:23][N:24]2[C:29]1[CH:30]=[CH:31][C:32]([F:35])=[CH:33][CH:34]=1)([OH:36])[C:16]([F:42])([F:43])[F:15])[C:4](=[O:5])[C:3]1[C:7]([C:11]([F:14])([F:13])[F:12])=[CH:8][CH:9]=[CH:10][C:2]=1[F:1])[CH3:40]