2-Fluoro-6-(trifluoromethyl)benzoyl chloride → N-Ethyl-2-fluoro-N-[3,3,3-trifluoro-2-({[1-(4-fluorophenyl)-1H-indazol-4-yl]amino}methyl)-2-hydroxypropyl]-6-(trifluoromethyl)benzamide

HRID 551489Notes

Reaction equation

HRID 551489 reaction equation
[F:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]([C:11]([F:14])([F:13])[F:12])[C:3]=1[C:4](Cl)=[O:5].[F:15][C:16]([F:43])([F:42])[C:17]([CH2:37][NH:38][CH2:39][CH2:40]C)([OH:36])[CH2:18][NH:19][C:20]1[CH:28]=[CH:27][CH:26]=[C:25]2[C:21]=1[CH:22]=[N:23][N:24]2[C:29]1[CH:34]=[CH:33][C:32]([F:35])=[CH:31][CH:30]=1>>[CH2:39]([N:38]([CH2:37][C:17]([CH2:18][NH:19][C:20]1[CH:28]=[CH:27][CH:26]=[C:25]2[C:21]=1[CH:22]=[N:23][N:24]2[C:29]1[CH:30]=[CH:31][C:32]([F:35])=[CH:33][CH:34]=1)([OH:36])[C:16]([F:42])([F:43])[F:15])[C:4](=[O:5])[C:3]1[C:7]([C:11]([F:14])([F:13])[F:12])=[CH:8][CH:9]=[CH:10][C:2]=1[F:1])[CH3:40]

Participants

3

Reactant 2

HCID 1454582-Fluoro-6-(trifluoromethyl)benzoyl chlorideHCID 593241371,1,1-Trifluoro-3-{[1-(4-fluorophenyl)-1H-indazol-4-yl]amino}-2-[(propylamino)methyl]-2-propanol

Product 1

HCID 59324135N-Ethyl-2-fluoro-N-[3,3,3-trifluoro-2-({[1-(4-fluorophenyl)-1H-indazol-4-yl]amino}methyl)-2-hydroxypropyl]-6-(trifluoromethyl)benzamide

Procedure

Prepared similarly to Example 48 from 2-fluoro-6-(trifluoromethyl)benzoyl chloride and 1,1,1-trifluoro-3-{[1-(4-fluorophenyl)-1H-indazol-4-yl]amino}-2-[(propylamino)methyl]-2-propanol.

Sources & evidence

ORD record
ord-aa2770bcfa144d55b21d0108cd326fb3
Source dataset
uspto-grants-2011_05
Patent number
US07947727B2

Reaction notes

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