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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 551489Generated: October 31, 2026

2-Fluoro-6-(trifluoromethyl)benzoyl chloride → N-Ethyl-2-fluoro-N-[3,3,3-trifluoro-2-({[1-(4-fluorophenyl)-1H-indazol-4-yl]amino}methyl)-2-hydroxypropyl]-6-(trifluoromethyl)benzamide

https://huagongshe.com/reaction/551489

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Fluoro-6-(trifluoromethyl)benzoyl chlorideHCID 145458—
Reactant1,1,1-Trifluoro-3-{[1-(4-fluorophenyl)-1H-indazol-4-yl]amino}-2-[(propylamino)methyl]-2-propanolHCID 59324137—
ProductN-Ethyl-2-fluoro-N-[3,3,3-trifluoro-2-({[1-(4-fluorophenyl)-1H-indazol-4-yl]amino}methyl)-2-hydroxypropyl]-6-(trifluoromethyl)benzamideHCID 59324135—

Reaction Steps

Prepared similarly to Example 48 from 2-fluoro-6-(trifluoromethyl)benzoyl chloride and 1,1,1-trifluoro-3-{[1-(4-fluorophenyl)-1H-indazol-4-yl]amino}-2-[(propylamino)methyl]-2-propanol.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07947727B2
Source datasetuspto-grants-2011_05
ORD IDord-aa2770bcfa144d55b21d0108cd326fb3
Source noteuspto-grants-2011_05