2-Fluoro-6-(trifluoromethyl)benzoyl chloride → N-Ethyl-2-fluoro-N-[3,3,3-trifluoro-2-({[1-(4-fluorophenyl)-6-methyl-1H-indazol-4-yl]amino}methyl)-2-hydroxypropyl]-6-(trifluoromethyl)benzamide

HRID 551490Notes

Reaction equation

HRID 551490 reaction equation
[F:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]([C:11]([F:14])([F:13])[F:12])[C:3]=1[C:4](Cl)=[O:5].[CH2:15]([NH:17][CH2:18][C:19]([CH2:25][NH:26][C:27]1[CH:35]=[C:34]([CH3:36])[CH:33]=[C:32]2[C:28]=1[CH:29]=[N:30][N:31]2[C:37]1[CH:42]=[CH:41][C:40]([F:43])=[CH:39][CH:38]=1)([OH:24])[C:20]([F:23])([F:22])[F:21])[CH3:16]>>[CH2:15]([N:17]([CH2:18][C:19]([CH2:25][NH:26][C:27]1[CH:35]=[C:34]([CH3:36])[CH:33]=[C:32]2[C:28]=1[CH:29]=[N:30][N:31]2[C:37]1[CH:38]=[CH:39][C:40]([F:43])=[CH:41][CH:42]=1)([OH:24])[C:20]([F:22])([F:23])[F:21])[C:4](=[O:5])[C:3]1[C:7]([C:11]([F:14])([F:13])[F:12])=[CH:8][CH:9]=[CH:10][C:2]=1[F:1])[CH3:16]

Participants

3

Reactant 2

HCID 1454582-Fluoro-6-(trifluoromethyl)benzoyl chlorideHCID 593241453-(Ethylamino)-1,1,1-trifluoro-2-({[1-(4-fluorophenyl)-6-methyl-1H-indazol-4-yl]amino}methyl)-2-propanol

Product 1

HCID 59324143N-Ethyl-2-fluoro-N-[3,3,3-trifluoro-2-({[1-(4-fluorophenyl)-6-methyl-1H-indazol-4-yl]amino}methyl)-2-hydroxypropyl]-6-(trifluoromethyl)benzamide

Procedure

Prepared similarly to Example 48 from 2-fluoro-6-(trifluoromethyl)benzoyl chloride and 3-(ethylamino)-1,1,1-trifluoro-2-({[1-(4-fluorophenyl)-6-methyl-1H-indazol-4-yl]amino}methyl)-2-propanol.

Sources & evidence

ORD record
ord-3bd00bb9d8f04397ab5d875d56bbcb01
Source dataset
uspto-grants-2011_05
Patent number
US07947727B2

Reaction notes

Loading…