HRID551490

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID145458

2-Fluoro-6-(trifluoromethyl)benzoyl chloride

C8H3ClF4O

结构：CCNCC(O)(CNc1cc(C)cc2c1cnn2-c1ccc(F)cc1)C(F)(F)F

HCID59324145

未命名化合物

PRODUCTS

生成物

结构：CCN(CC(O)(CNc1cc(C)cc2c1cnn2-c1ccc(F)cc1)C(F)(F)F)C(=O)c1c(F)cccc1C(F)(F)F

HCID59324143

未命名化合物

PROCEDURE

实验过程

Prepared similarly to Example 48 from 2-fluoro-6-(trifluoromethyl)benzoyl chloride and 3-(ethylamino)-1,1,1-trifluoro-2-({[1-(4-fluorophenyl)-6-methyl-1H-indazol-4-yl]amino}methyl)-2-propanol.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-3bd00bb9d8f04397ab5d875d56bbcb01
来源数据集: uspto-grants-2011_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07947727B2
来源说明: uspto-grants-2011_05

反应 SMILES

[F:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]([C:11]([F:14])([F:13])[F:12])[C:3]=1[C:4](Cl)=[O:5].[CH2:15]([NH:17][CH2:18][C:19]([CH2:25][NH:26][C:27]1[CH:35]=[C:34]([CH3:36])[CH:33]=[C:32]2[C:28]=1[CH:29]=[N:30][N:31]2[C:37]1[CH:42]=[CH:41][C:40]([F:43])=[CH:39][CH:38]=1)([OH:24])[C:20]([F:23])([F:22])[F:21])[CH3:16]>>[CH2:15]([N:17]([CH2:18][C:19]([CH2:25][NH:26][C:27]1[CH:35]=[C:34]([CH3:36])[CH:33]=[C:32]2[C:28]=1[CH:29]=[N:30][N:31]2[C:37]1[CH:38]=[CH:39][C:40]([F:43])=[CH:41][CH:42]=1)([OH:24])[C:20]([F:22])([F:23])[F:21])[C:4](=[O:5])[C:3]1[C:7]([C:11]([F:14])([F:13])[F:12])=[CH:8][CH:9]=[CH:10][C:2]=1[F:1])[CH3:16]