6-(4',5'-difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-1H-indole → 4-(4',5'-Difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-1H-indole

HRID 551511Notes

Reaction equation

HRID 551511 reaction equation
FC1C(F)=CC(C2C=CC(OCC3C=C4C(C=CN4)=CC=3)=CC=2)=C(OC)C=1.C(OC([N:35]1[C:43]2[C:38](=[C:39]([CH2:44][O:45][C:46]3[CH:51]=[CH:50][C:49]([C:52]4[CH:57]=[C:56]([F:58])[C:55]([F:59])=[CH:54][C:53]=4[O:60][CH3:61])=[CH:48][CH:47]=3)[CH:40]=[CH:41][CH:42]=2)[CH:37]=[CH:36]1)=O)(C)(C)C>>[F:59][C:55]1[C:56]([F:58])=[CH:57][C:52]([C:49]2[CH:50]=[CH:51][C:46]([O:45][CH2:44][C:39]3[CH:40]=[CH:41][CH:42]=[C:43]4[C:38]=3[CH:37]=[CH:36][NH:35]4)=[CH:47][CH:48]=2)=[C:53]([O:60][CH3:61])[CH:54]=1

Participants

3

Reactant 2

HCID 529398626-(4',5'-difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-1H-indoleHCID 671519404-(4',5'-Difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-indole-1-carboxylic acid tert-butyl ester

Product 1

HCID 529397424-(4',5'-Difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-1H-indole

Procedure

4-(4′,5′-Difluoro-2′-methoxy-biphenyl-4-yloxymethyl)-1H-indole was synthesized by a procedure similar to 6-(4′,5′-difluoro-2′-methoxy-biphenyl-4-yloxymethyl)-1H-indole from starting material 4-(4′,5′-difluoro-2′-methoxy-biphenyl-4-yloxymethyl)-indole-1-carboxylic acid tert-butyl ester to yield the product was a white solid (156 mg, 99%). LC-MS (ES) calculated for C22H17F2NO2, 365.1; found m/z 366 [M+H]+.

Workup

  1. customto yield the product

Sources & evidence

ORD record
ord-1334676a2f504b328401b70b7ac6772d
Source dataset
uspto-grants-2011_05
Patent number
US07947728B1

Reaction notes

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