反应详情

3-[4-(4′,5′-Difluoro-2′-methoxy-biphenyl-4-yloxymethyl)-indol-1-yl]-butyric acid was synthesized by a procedure similar to 3-[6-(4′,5′-difluoro-2′-methoxy-biphenyl-4-yloxymethyl)-indol-1-yl]-butyric acid from starting materials 4-(4′,5′-difluoro-2′-methoxy-biphenyl-4-yloxymethyl)-1H-indole and (E)-but-2-enoic acid ethyl ester to yield the product as a clear to opaque oil/film (6 mg, 13%). LC-MS (ES) calculated for C26H23F2NO4, 451.2; found m/z 452 [M+H]+.