HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl trans-crotonate → 3-[4-(4',5'-Difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-indol-1-yl]-butyric acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl trans-crotonate | HCID 429065 | — |
| Reactant | 3-[6-(4',5'-Difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-indol-1-yl]-butyric acid | HCID 52939741 | — |
| Reactant | 4-(4',5'-Difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-1H-indole | HCID 52939742 | — |
| Product | 3-[4-(4',5'-Difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-indol-1-yl]-butyric acid | HCID 52939865 | — |
Reaction Steps
3-[4-(4′,5′-Difluoro-2′-methoxy-biphenyl-4-yloxymethyl)-indol-1-yl]-butyric acid was synthesized by a procedure similar to 3-[6-(4′,5′-difluoro-2′-methoxy-biphenyl-4-yloxymethyl)-indol-1-yl]-butyric acid from starting materials 4-(4′,5′-difluoro-2′-methoxy-biphenyl-4-yloxymethyl)-1H-indole and (E)-but-2-enoic acid ethyl ester to yield the product as a clear to opaque oil/film (6 mg, 13%). LC-MS (ES) calculated for C26H23F2NO4, 451.2; found m/z 452 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07947728B1 |
| Source dataset | uspto-grants-2011_05 |
| ORD ID | ord-61fcac5296d046dca4cc18d7023f5e61 |
| Source note | uspto-grants-2011_05 |