HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 5-(2-Aminoethyl)-2-methoxyphenylamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | N-(3-Amino-4-methoxyphenethyl)acetamide hydrochloride | HCID 45074592 | — |
| Product | 5-(2-Aminoethyl)-2-methoxyphenylamine | HCID 23319767 | 94% |
Reaction Steps
N-[-2-(3-amino-4-methoxyphenyl)ethyl]acetamide hydrochloride, prepared as described in Example 8 (15 g) and 175 mL of 2N HCl were heated at reflux for 6 hours. The solvent was removed by rotary evaporation, and the residue was washed with ethanol. The resulting white precipitate was filtered off and dried in vacuum, yielding 13.7 g (94%) of 5-(2-aminoethyl)-2-methoxyphenylamine (AMMPA) dihydrochloride as white crystals. 1HNMR (DMSO-d6) spectrum was consistent with the desired product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07947761B2 |
| Source dataset | uspto-grants-2011_05 |
| ORD ID | ord-2e7c11cc7b2848d7b50355063670ea45 |
| Source note | uspto-grants-2011_05 |