反应详情

N-[-2-(3-amino-4-methoxyphenyl)ethyl]acetamide hydrochloride, prepared as described in Example 8 (15 g) and 175 mL of 2N HCl were heated at reflux for 6 hours. The solvent was removed by rotary evaporation, and the residue was washed with ethanol. The resulting white precipitate was filtered off and dried in vacuum, yielding 13.7 g (94%) of 5-(2-aminoethyl)-2-methoxyphenylamine (AMMPA) dihydrochloride as white crystals. 1HNMR (DMSO-d6) spectrum was consistent with the desired product.

1. temperaturewere heated
2. temperatureat reflux for 6 hours
3. customThe solvent was removed by rotary evaporation
4. washthe residue was washed with ethanol
5. filtrationThe resulting white precipitate was filtered off
6. customdried in vacuum