Triethylamine → HCID 59509753, compound

HRID 551684Notes

Reaction equation

HRID 551684 reaction equation
C1(S(O)(=O)=O)C=CC=CC=1.C(OC([NH:18][CH2:19][C@:20]1([CH2:28][C:29]([OH:31])=[O:30])[CH2:26][C@@H:25]2[C@H:21]1[CH:22]=[C:23]([CH3:27])[CH2:24]2)=O)(C)(C)C.C(N(CC)CC)C>C(Cl)Cl>[NH2:18][CH2:19][C@:20]1([CH2:28][C:29]([OH:31])=[O:30])[CH2:26][C@@H:25]2[C@H:21]1[CH:22]=[C:23]([CH3:27])[CH2:24]2

Participants

4

Reactant 2

HCID 8471TriethylamineHCID 86646150HCID 86646150, compound

Product 1

HCID 59509753HCID 59509753, compoundYield 77.8%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

[(1R,5S,6S)-6-tert-butoxycarbonylaminomethyl-3-methylbicyclo[3.2.0]hept-3-en-6-yl]acetic acid benzenesulfonic acid (5.6 g, 15.8 mmol) was suspended in methylene chloride (50 mL). To the suspension, triethylamine (4.4 ml, 31.7 mmol) was added, and the mixture was stirred at room temperature for 1 hour. The resulting solid was collected by filtration and washed with isopropanol to obtain the compound of interest as a white solid (2.4 g, 77%).

Workup

  1. filtrationThe resulting solid was collected by filtration
  2. washwashed with isopropanol

Sources & evidence

ORD record
ord-11c0bc71ff534ec4a79d3b515ffc3d36
Source dataset
uspto-grants-2011_05
Patent number
US07947738B2

Reaction notes

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