Triethylamine → HCID 49802950, compound

HRID 551686Notes

Reaction equation

HRID 551686 reaction equation
C1(S(O)(=O)=O)C=CC=CC=1.C(OC([NH:18][CH2:19][C@@:20]1([CH2:28][C:29]([OH:31])=[O:30])[CH2:26][C@H:25]2[C@@H:21]1[CH:22]=[C:23]([CH3:27])[CH2:24]2)=O)(C)(C)C.C(N(CC)CC)C>C(Cl)Cl>[NH2:18][CH2:19][C@@:20]1([CH2:28][C:29]([OH:31])=[O:30])[CH2:26][C@H:25]2[C@@H:21]1[CH:22]=[C:23]([CH3:27])[CH2:24]2

Participants

4

Reactant 2

HCID 8471TriethylamineHCID 86646153HCID 86646153, compound

Product 1

HCID 49802950HCID 49802950, compoundYield 63%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

[(1S,5R,6R)-6-tert-butoxycarbonylaminomethyl-3-methylbicyclo[3.2.0]hept-3-en-6-yl]acetic acid benzenesulfonic acid (5.8 g, 16.4 mmol) was suspended in methylene chloride (50 mL). To the suspension, triethylamine (4.6 ml, 32.7 mmol) was added, and the mixture was stirred at room temperature for 1 hour. The resulting solid was collected by filtration and washed with isopropanol to obtain the compound of interest as a white solid (2.0 g, 63%).

Workup

  1. filtrationThe resulting solid was collected by filtration
  2. washwashed with isopropanol

Sources & evidence

ORD record
ord-1084e05037674d9880ef8d65652d6bff
Source dataset
uspto-grants-2011_05
Patent number
US07947738B2

Reaction notes

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