反应详情

The compound obtained in Step F (7.7 mmol) is dissolved in 200 ml of anhydrous dichloromethane. The resulting solution is added to a suspension of potassium acetate (0.23 g) and pyridinium chlorochromate (11.6 mmol) in 50 ml of dichloromethane. The reaction mixture is stirred at ambient temperature for 2 hours. It is then filtered over Celite. The filtrate is washed with water, decolourised on vegetable carbon and evaporated under reduced pressure. The residue obtained is triturated in diethyl ether, filtered off under suction and recrystallised from diisopropyl ether to yield the title product in the form of a white solid.

1. filtrationIt is then filtered over Celite
2. washThe filtrate is washed with water
3. customevaporated under reduced pressure
4. customThe residue obtained
5. customis triturated in diethyl ether
6. filtrationfiltered off under suction
7. customrecrystallised from diisopropyl ether