反应详情

In a 100-ml round-bottom flask, the compound obtained in Step G (4.2 mmol) is dissolved in 25 ml of methanol. Hydroxylamine hydrochloride (16.8 mmol) and pyridine (21.1 mmol) are added and then the reaction mixture is heated at reflux, with magnetic stirring, for 3 hours. After cooling, the reaction mixture is poured into 50 ml of water. The precipitate formed is filtered off under suction, washed with water and recrystallised from toluene to yield the title product in the form of a white solid.

1. temperaturethe reaction mixture is heated
2. temperatureat reflux, with magnetic stirring, for 3 hours
3. temperatureAfter cooling
4. customThe precipitate formed
5. filtrationis filtered off under suction
6. washwashed with water
7. customrecrystallised from toluene