反应详情

1.54 ml of a 4N solution of hydrochloric acid in dioxane are added dropwise using a dropping funnel to a 25 ml round-bottomed flask comprising 0.552 g of tert-butyl 4-(pyridin-4-yl)piperidine-1-carboxylate. Stirring is maintained for 1 hour. The product is subsequently concentrated under vacuum and then treated with a 1N aqueous sodium hydroxide solution. The aqueous phase is extracted 3 times with dichloromethane. The organic phase is dried over sodium sulfate and concentrated under reduced pressure. 0.341 g of 4-(piperidin-4-yl)pyridine is obtained.

1. temperatureis maintained for 1 hour
2. concentrationThe product is subsequently concentrated under vacuum
3. additiontreated with a 1N aqueous sodium hydroxide solution
4. extractionThe aqueous phase is extracted 3 times with dichloromethane
5. dry with materialThe organic phase is dried over sodium sulfate
6. concentrationconcentrated under reduced pressure