HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 1-[(4-(Pyridin-4-yl)piperidin-1-yl)carbonyl]-1,2,3,4-tetrahydroquinoline hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 1-[(4-(Pyridin-4-yl)piperidin-1-yl)carbonyl]-1,2,3,4-tetrahydroquinoline | HCID 24852909 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 1-[(4-(Pyridin-4-yl)piperidin-1-yl)carbonyl]-1,2,3,4-tetrahydroquinoline hydrochloride | HCID 24852908 | — |
Reaction Steps
0.11 g of 1-[(4-(pyridin-4-yl)piperidin-1-yl)carbonyl]-1,2,3,4-tetrahydroquinoline, dissolved in 3 ml of dichloromethane, is introduced into a 25 ml round-bottomed flask. 3.5 ml of a 0.2N solution of hydrochloric acid in ether are subsequently added. Stirring is maintained for 10 min. After evaporating, the residue is taken up in ethyl acetate. The precipitate is filtered off then dried under vacuum. 0.09 g of 1-[(4-(pyridin-4-yl)piperidin-1-yl)carbonyl]-1,2,3,4-tetrahydroquinoline hydrochloride is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07947834B2 |
| Source dataset | uspto-grants-2011_05 |
| ORD ID | ord-1e95f9204527467d9f8340ece9eba470 |
| Source note | uspto-grants-2011_05 |