反应详情

温度

0 °C

To a mixture of 1.1 mmol of 4-[(2-methylbenzoyl)amino]benzoyl chloride in 10 ml of methylene chloride, cooled to 0° C. is added 1.5 mmol of triethylamine. To the mixture is added 1 mmol of 9,10-dihydro-4H-furo[2,3-e]pyrrolo[1,2-a][1,4]diazepine and the mixture stirred at room temperature for 2 hours. The reaction mixture is concentrated in vacuo and the residue is dissolved in 100 ml of ethyl acetate and washed with water, 2N citric acid, aqueous NaHCO3 and brine. The solution is dried with Na2SO4 and the volatiles concentrated in vacuo to give a solid which is purified by flash chromatography to give the desired product.

1. concentrationThe reaction mixture is concentrated in vacuo
2. dissolutionthe residue is dissolved in 100 ml of ethyl acetate
3. washwashed with water, 2N citric acid, aqueous NaHCO3 and brine
4. dry with materialThe solution is dried with Na2SO4
5. concentrationthe volatiles concentrated in vacuo
6. customto give a solid which
7. customis purified by flash chromatography