反应详情

0.21 g of {4-[(3-(pyridin-3-yl)pyrrolidin-1-yl)carbonyl]-3,4-dihydro-2H-1,4-benzoxazin-6-yl}methanol, dissolved in 6.19 ml of a 0.1N solution of hydrochloric acid in ether, is introduced into a 50 ml round-bottomed flask. Stirring is maintained for ten minutes. After evaporating, the residue is triturated in ethyl ether and then the solid is filtered off in order to obtain, after drying under vacuum, 0.108 g of {4-[(3-(pyridin-3-yl)pyrrolidin-1-yl)carbonyl]-3,4-dihydro-2H-1,4-benzoxazin-6-yl}methanol hydrochloride.

1. additionis introduced into a 50 ml round-bottomed flask
2. temperatureis maintained for ten minutes
3. customAfter evaporating
4. customthe residue is triturated in ethyl ether
5. filtrationthe solid is filtered off in order
6. customto obtain
7. dry with materialafter drying under vacuum, 0.108 g of {4-[(3-(pyridin-3-yl)pyrrolidin-1-yl)carbonyl]-3,4-dihydro-2H-1,4-benzoxazin-6-yl}methanol hydrochloride