Sodium borohydride → HCID 10870927, compound

HRID 551835Notes

Reaction equation

HRID 551835 reaction equation
[CH3:1][O:2][C@H:3]1[CH2:20][CH2:19][C@@:18]2([CH3:21])[C:5](=[CH:6][C:7](=[O:23])[C@@H:8]3[C@@H:17]2[CH2:16][CH2:15][C@@:13]2([CH3:14])[C@H:9]3[CH2:10][CH2:11][C:12]2=[O:22])[CH2:4]1.[BH4-].[Na+]>C(Cl)Cl.CO>[CH3:1][O:2][C@H:3]1[CH2:20][CH2:19][C@@:18]2([CH3:21])[C:5](=[CH:6][C@H:7]([OH:23])[C@@H:8]3[C@@H:17]2[CH2:16][CH2:15][C@@:13]2([CH3:14])[C@H:9]3[CH2:10][CH2:11][C@@H:12]2[OH:22])[CH2:4]1

Participants

4

Reactant 2

HCID 4311764Sodium borohydrideHCID 11141634HCID 11141634, compound

Product 1

HCID 10870927HCID 10870927, compound

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

24 was prepared by reduction of 3β-methoxyandrost-5-ene-7,17-dione 20, with sodium borohydride in a mixture of methylene dichloride-methanol at room temperature. The product was purified by column chromatography.

Workup

  1. customThe product was purified by column chromatography

Sources & evidence

ORD record
ord-51a5c272897e4d1e8591c91778a0121e
Source dataset
uspto-grants-2011_05
Patent number
US07947846B2

Reaction notes

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