Allyl chloroformate → 3beta-Carboallyloxyandrost-5-ene-7,17-dione

Beteiligte Stoffe

Reaktionsschritte

Compound 43 was prepared from 7-oxo-DHEA (2) (1.0 mmol) and allylchloroformate (4.0 mmol) in tetrahydrofuran-pyridine mixture at 0-5° C. After stirring 6 hours only 30% conversion had occurred; from the mixture the product was isolated in 78% yield (based on 30% conversion) by column chromatography. M.p. 159-61° C.

Herkunft & Nachweise