Tetrahydrofuran → 5-[{4-[(4-butylphenyl)ethynyl]benzyl}(hexyl)amino]-2-hydroxybenzoic acid N-methyl-D-glucamine

Participants

Reaction Steps

To a solution of the 5-[{4-[(4-butylphenyl)ethynyl]benzyl}(hexyl)amino]-2-hydroxybenzoic acid (1650 mg, 3.41 mmol) in freshly distilled THF (20 mL) was added a solution of N-methyl-D-glucamine (666 mg) in water (4 mL). Water (200 mL) was added and the resulting solution was lyophilized to give 1.93 g (81%) of the title compound as a pale yellow powder. HPLC, Rt: 4.8 min (purity: 98.8%). LC/MS, M+(ESI): 484.0, M−(ESI): 482.0.

Provenance & Evidence