HRID551892

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID8028

Tetrahydrofuran

C4H8O

结构：CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO

HCID8567

(2R,3R,4R,5S)-6-(Methylamino)hexane-1,2,3,4,5-pentol

C7H17NO5

结构：CCCCCCN(Cc1ccc(C#Cc2ccc(CCCC)cc2)cc1)c1ccc(O)c(C(=O)O)c1

HCID11497282

未命名化合物

PRODUCTS

生成物

结构：CCCCCCN(Cc1ccc(C#Cc2ccc(CCCC)cc2)cc1)c1ccc(O)c(C(=O)O)c1.CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO

HCID11520358

未命名化合物

收率 83.4%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID962

Water

H2O

2 次

PROCEDURE

实验过程

To a solution of the 5-[{4-[(4-butylphenyl)ethynyl]benzyl}(hexyl)amino]-2-hydroxybenzoic acid (1650 mg, 3.41 mmol) in freshly distilled THF (20 mL) was added a solution of N-methyl-D-glucamine (666 mg) in water (4 mL). Water (200 mL) was added and the resulting solution was lyophilized to give 1.93 g (81%) of the title compound as a pale yellow powder. HPLC, Rt: 4.8 min (purity: 98.8%). LC/MS, M+(ESI): 484.0, M−(ESI): 482.0.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-e6bcb7b2254c4597aec88fe455bf6890
来源数据集: uspto-grants-2011_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07947851B2
来源说明: uspto-grants-2011_05

反应 SMILES

[CH2:1]([C:5]1[CH:10]=[CH:9][C:8]([C:11]#[C:12][C:13]2[CH:36]=[CH:35][C:16]([CH2:17][N:18]([CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH3:34])[C:19]3[CH:20]=[CH:21][C:22]([OH:28])=[C:23]([CH:27]=3)[C:24]([OH:26])=[O:25])=[CH:15][CH:14]=2)=[CH:7][CH:6]=1)[CH2:2][CH2:3][CH3:4].C1COCC1.[CH3:42][NH:43][CH2:44][C@@H:45]([C@H:47]([C@@H:49]([C@@H:51]([CH2:53][OH:54])[OH:52])[OH:50])[OH:48])[OH:46]>O>[CH3:42][NH:43][CH2:44][C@@H:45]([C@H:47]([C@@H:49]([C@@H:51]([CH2:53][OH:54])[OH:52])[OH:50])[OH:48])[OH:46].[CH2:1]([C:5]1[CH:6]=[CH:7][C:8]([C:11]#[C:12][C:13]2[CH:36]=[CH:35][C:16]([CH2:17][N:18]([CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH3:34])[C:19]3[CH:20]=[CH:21][C:22]([OH:28])=[C:23]([CH:27]=3)[C:24]([OH:26])=[O:25])=[CH:15][CH:14]=2)=[CH:9][CH:10]=1)[CH2:2][CH2:3][CH3:4]