反应详情

To a mixture of 5 mmol of 5,6-dihydro-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepine in 20 ml of dichloromethane is added 5.5 mmol of 4-[(2-methylbenzoyl)amino]benzoyl chloride and 7.5 mmol of triethylamine. The mixture is stirred at room temperature for 8 hours and then washed with water, aqueous NaHCO3 and brine. The organic layer is dried (Na2SO4) and the solvent removed in vacuo to give a solid. The solid is purified by chromatography on silica gel with ethyl acetate-hexane as solvent to give the desired product.

1. washwashed with water, aqueous NaHCO3 and brine
2. dry with materialThe organic layer is dried (Na2SO4)
3. customthe solvent removed in vacuo
4. customto give a solid
5. customThe solid is purified by chromatography on silica gel with ethyl acetate-hexane as solvent