Methanol → Methyl 2-aminoisobutyrate hydrochloride

HRID 552059Notes

Reaction equation

[NH2:1][C:2]([CH3:7])([CH3:6])[C:3]([OH:5])=[O:4].S(Cl)([Cl:10])=O.[CH3:12]O>>[ClH:10].[CH3:12][O:4][C:3](=[O:5])[C:2]([NH2:1])([CH3:7])[CH3:6]

Participants

Reactant 3

HCID 887Methanol

HCID 6119Aminoisobutyric acid

HCID 24386Thionyl Chloride

Product 1

HCID 13258034Methyl 2-aminoisobutyrate hydrochlorideYield 89.2%

Procedure

This was synthesised according to Standard Procedure 1, using 2-amino-isobutyric acid (5.102 g, 48.49 mmol) with thionyl chloride (11.538 g, 96.98 mmol, 7.04 mL) and anhydrous methanol (19.6 mL). The product was isolated as a white solid (6.636 g, yield 89.2%).

Workup

customThis was synthesised

Sources & evidence

ORD record: ord-4dc15b2cdeb2425d8b6f619f0f17144b
Source dataset: uspto-grants-2011_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07951787B2

Reaction notes

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