Ethanol → Ethyl 2-amino-2-methylpropanoate hydrochloride

HRID 552060Notes

Reaction equation

[NH2:1][C:2]([CH3:7])([CH3:6])[C:3]([OH:5])=[O:4].S(Cl)([Cl:10])=O.[CH2:12](O)[CH3:13]>>[ClH:10].[CH2:12]([O:4][C:3](=[O:5])[C:2]([NH2:1])([CH3:7])[CH3:6])[CH3:13]

Participants

Reactant 3

HCID 702Ethanol

HCID 6119Aminoisobutyric acid

HCID 24386Thionyl Chloride

Product 1

HCID 22343822Ethyl 2-amino-2-methylpropanoate hydrochlorideYield 86.3%

Procedure

This was synthesised according to Standard Procedure 1, using 2-amino-isobutyric acid (5.102 g, 48.49 mmol) with thionyl chloride (11.772 g, 98.95 mmol, 7.2 mL) and anhydrous ethanol (29 mL). The product was isolated as a white solid (7.159 g, yield 86.3%).

Workup

customThis was synthesised

Sources & evidence

ORD record: ord-94bd2d8a88fd4eeead367b1a1d1dc969
Source dataset: uspto-grants-2011_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07951787B2

Reaction notes

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