Dichloromethane → HCID 131728929, compound

HRID 552064Notes

Reaction equation

HRID 552064 reaction equation
Cl.[CH3:2][O:3][C:4](=[O:9])[C:5]([NH2:8])([CH3:7])[CH3:6].[P:10]([Cl:20])(Cl)([O:12][C:13]1[CH:18]=[CH:17]C=[CH:15][CH:14]=1)=[O:11].[CH2:21](Cl)Cl>>[C:2]1([O:3][C:4](=[O:9])[C:5]([NH2:8])([CH3:7])[CH2:6][CH3:21])[CH:17]=[CH:18][CH:13]=[CH:14][CH:15]=1.[P:10]([Cl:20])(=[O:11])([O-:12])[O-:3]

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 13038Phosphorodichloridic acid, phenyl esterHCID 13258034Methyl 2-aminoisobutyrate hydrochloride

Product 1

HCID 131728929HCID 131728929, compoundYield 95.2%

Procedure

This is synthesised according to Standard procedure 4, using 2-aminoisobutyrate methyl ester hydrochloride (583.5 mg, 3.75 mmol), phenyl dichlorophosphate (791.1 mg, 3.75, 560 μL), and TEA (758.9 mg, 7.5 mmol, 1045 μL) in DCM (20 mL), to yield 1.041 g (95.2%) of crude product used without further purification.

Workup

  1. customThis is synthesised

Sources & evidence

ORD record
ord-35259695a22b469f9459ef04aea0ea36
Source dataset
uspto-grants-2011_05
Patent number
US07951787B2

Reaction notes

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