Hydrochloric Acid → HCID 135484607, compound

HRID 552067Notes

Reaction equation

HRID 552067 reaction equation
[CH3:1][C:2]1[S:6][C:5]2[NH:7][C:8]3[CH:9]=[CH:10][CH:11]=[CH:12][C:13]=3[N:14]=[C:15]([N:16]3[CH2:21][CH2:20][N:19]([CH3:22])[CH2:18][CH2:17]3)[C:4]=2[CH:3]=1.[ClH:23]>C(#N)C.O1CCOCC1>[ClH:23].[ClH:23].[CH3:1][C:2]1[S:6][C:5]2[NH:7][C:8]3[CH:9]=[CH:10][CH:11]=[CH:12][C:13]=3[N:14]=[C:15]([N:16]3[CH2:21][CH2:20][N:19]([CH3:22])[CH2:18][CH2:17]3)[C:4]=2[CH:3]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 135398745Olanzapine

Product 1

HCID 135484607HCID 135484607, compoundYield 97.3%

Reagents, catalysts & solvents 2

HCID 6342AcetonitrileSolventHCID 312751,4-DioxaneSolvent

Procedure

1 g (3.2 mmoles) of olanzapine base is dissolved in 20 cm3 of acetonitrile by boiling in an apparatus equipped with a reflux condenser. Subsequently 3.4 g of hydrogen chloride solution in 1,4-dioxane (34.5 m/m %) are dropped to it. The mixture is cooled in ice-water for 10 minutes and the precipitated yellow product is filtered off. Thus 1.20 g (97%) of the title compound is obtained.

Workup

  1. customequipped with a reflux condenser
  2. filtrationthe precipitated yellow product is filtered off

Sources & evidence

ORD record
ord-ae6597d03f8c4b059786ff11e5321df2
Source dataset
uspto-grants-2011_05
Patent number
US07951798B2

Reaction notes

Loading…