Hydrochloric Acid → 783334-36-1

Participants

Reaction Steps

In an apparatus equipped with a reflux condenser 1 g (3.2 mmoles) of olanzapine base is dissolved in 20 cm3 of acetonitrile by heating until boiling. Subsequently 3.2 g of concentrated aqueous hydrochloric acid solution are dropped to it (37.0 g of hydrogen chloride in 100 cm3 of water). The reaction mixture is cooled for 10 minutes in an ice-water bath and the yellow precipitate is filtered off. Thus 1.1 g (98.5%) of the title compound is obtained.

Provenance & Evidence