Hydrochloric Acid → 783334-36-1

HRID 552071Notes

Reaction equation

HRID 552071 reaction equation
[CH3:1][C:2]1[S:6][C:5]2[NH:7][C:8]3[CH:9]=[CH:10][CH:11]=[CH:12][C:13]=3[N:14]=[C:15]([N:16]3[CH2:21][CH2:20][N:19]([CH3:22])[CH2:18][CH2:17]3)[C:4]=2[CH:3]=1.[ClH:23]>C(#N)C.O>[ClH:23].[CH3:1][C:2]1[S:6][C:5]2[NH:7][C:8]3[CH:9]=[CH:10][CH:11]=[CH:12][C:13]=3[N:14]=[C:15]([N:16]3[CH2:21][CH2:20][N:19]([CH3:22])[CH2:18][CH2:17]3)[C:4]=2[CH:3]=1

Participants

5

Reactant 2

HCID 313Hydrochloric Acid2×HCID 135398745Olanzapine

Product 1

HCID 135566004783334-36-1Yield 98.5%

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6342AcetonitrileSolvent

Procedure

In an apparatus equipped with a reflux condenser 1 g (3.2 mmoles) of olanzapine base is dissolved in 20 cm3 of acetonitrile by heating until boiling. Subsequently 3.2 g of concentrated aqueous hydrochloric acid solution are dropped to it (37.0 g of hydrogen chloride in 100 cm3 of water). The reaction mixture is cooled for 10 minutes in an ice-water bath and the yellow precipitate is filtered off. Thus 1.1 g (98.5%) of the title compound is obtained.

Workup

  1. temperatureby heating
  2. temperatureThe reaction mixture is cooled for 10 minutes in an ice-water bath
  3. filtrationthe yellow precipitate is filtered off

Sources & evidence

ORD record
ord-30b777a496424c01bd19b09fbb7176b8
Source dataset
uspto-grants-2011_05
Patent number
US07951798B2

Reaction notes

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