2-Aminopyrimidine-4-carbaldehyde → 2-(Methylamino)pyrimidine-4-carbaldehyde

HRID 552116Notes

Reaction equation

HRID 552116 reaction equation
NC1N=C(C=O)C=CN=1.C[O:11][CH:12](OC)[C:13]1[CH:18]=[CH:17][N:16]=[C:15]([NH:19][CH3:20])[N:14]=1>>[CH3:20][NH:19][C:15]1[N:14]=[C:13]([CH:12]=[O:11])[CH:18]=[CH:17][N:16]=1

Participants

3

Reactant 2

HCID 178323462-Aminopyrimidine-4-carbaldehydeHCID 178400144-(Dimethoxymethyl)-N-methylpyrimidin-2-amine

Product 1

HCID 220025312-(Methylamino)pyrimidine-4-carbaldehydeYield 30%

Procedure

2-Methylaminopyrimidine-4-carboxaldehyde (I-11) was synthesized in a similar manner to 2-aminopyrimidine-4-carboxaldehyde (I-9, procedure I). Reaction of crude 2-methylaminopyrimidine-4-carboxaldehyde dimethyl acetal (I-10) from procedure J provided 1.7 g (30% from dimethylformamide dimethyl acetal) of 2-methylaminopyrimidine-4-carboxaldehyde (I-11) as dark brown foam.

Sources & evidence

ORD record
ord-8a899afe176e40fc8869629906d81d8b
Source dataset
uspto-grants-2011_05
Patent number
US07951803B2

Reaction notes

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