反应详情

A solution of 4-(2-trifluoromethylphenylamino)piperidine-1-carboxylic acid tert-butyl ester (0.87 g, 2.52 mmol) in dichloromethane and trifluoroacetic acid (18 mL, 2:1) was stirred at ambient temperature overnight, the solvents were removed by evaporation. The residue was dissolved in ethyl acetate, and the resulting solution was washed with aqueous saturated NaHCO3 and brine, dried over anhydrous Na2SO4 and concentrated to give piperidin-4-yl-(2-trifluoromethylphenyl)amine (0.612 g, 99%) which was used directly for next step reaction without further purification. MS (ES+) m/z 245.0 (M+1).

1. customthe solvents were removed by evaporation
2. dissolutionThe residue was dissolved in ethyl acetate
3. washthe resulting solution was washed with aqueous saturated NaHCO3 and brine
4. dry with materialdried over anhydrous Na2SO4
5. concentrationconcentrated