Trifluoroacetic acid → 4-[2-(Trifluoromethyl)phenoxy]piperidine

Participants

Reaction Steps

To a stirred solution of 4-(2-trifluoromethylphenoxy)piperidine-1-carboxylic acid tert-butyl ester (1.413 g, 4.000 mmol) in dichloromethane (40.0 mL) was added trifluoroacetic acid (6.0 mL, 80.00 mmol). The resulting mixture was stirred at ambient temperature for 24 hours and then quenched with a saturated aqueous solution of Na2CO3 (10.0 mL). The organic phase was washed with water (20.0 mL), brine (20.0 mL), dried over MgSO4 and then concentrated in vacuo. The obtained crude product was used without further purification.

Provenance & Evidence