反应详情

To a stirred solution of 4-(2-trifluoromethylphenoxy)piperidine-1-carboxylic acid tert-butyl ester (1.413 g, 4.000 mmol) in dichloromethane (40.0 mL) was added trifluoroacetic acid (6.0 mL, 80.00 mmol). The resulting mixture was stirred at ambient temperature for 24 hours and then quenched with a saturated aqueous solution of Na2CO3 (10.0 mL). The organic phase was washed with water (20.0 mL), brine (20.0 mL), dried over MgSO4 and then concentrated in vacuo. The obtained crude product was used without further purification.

1. customquenched with a saturated aqueous solution of Na2CO3 (10.0 mL)
2. washThe organic phase was washed with water (20.0 mL), brine (20.0 mL)
3. dry with materialdried over MgSO4
4. concentrationconcentrated in vacuo
5. customThe obtained crude product
6. customwas used without further purification