HCID 67170729, compound → HCID 67172284, compound

HRID 552136Notes

Reaction equation

HRID 552136 reaction equation
[CH:1]1([CH2:4][CH2:5][NH:6][C:7]([C:9]2[N:10]=[N:11][C:12]([N:15]3[CH2:20][CH:19]4[CH:17]([CH:18]4[N:21](CC4C=CC=CC=4)CC4C=CC=CC=4)[CH2:16]3)=[CH:13][CH:14]=2)=[O:8])[CH2:3][CH2:2]1>CO.[Pd]>[CH:1]1([CH2:4][CH2:5][NH:6][C:7]([C:9]2[N:10]=[N:11][C:12]([N:15]3[CH2:16][CH:17]4[CH:19]([CH:18]4[NH2:21])[CH2:20]3)=[CH:13][CH:14]=2)=[O:8])[CH2:3][CH2:2]1

Participants

4

Reactant 1

HCID 67170729HCID 67170729, compound

Product 1

HCID 67172284HCID 67172284, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

To a stirred solution of 6-(6-dibenzylamino-3-azabicyclo[3.1.0]hex-3-yl)pyridazine-3-carboxylic acid (2-cyclopropylethyl)amide (0.415 g, 0.90 mmol) in methanol (10 mL) was added Pd/C (0.200 g, 12 mol %). The mixture was placed under an atmosphere of hydrogen for 3 days. The reaction mixture was filtered through celite and concentrated in vacuo. The crude title compound was obtained and used without further purification.

Workup

  1. filtrationThe reaction mixture was filtered through celite and
  2. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-ff5b104bfff04e5ca4ecf94e9caa3c7e
Source dataset
uspto-grants-2011_05
Patent number
US07951805B2

Reaction notes

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