反应详情

To a stirred solution of 4-(2-trifluoromethylphenylcarbamoyl)piperidine-1-carboxylic acid tert-butyl ester (0.450 g, 1.20 mmol) in dichloromethane (10 mL) was added trifluoroacetic acid (1.4 mL). The resulting mixture was stirred at ambient temperature for 16 hours and then quenched with saturated aqueous solution of Na2CO3 (10 mL). The organic phase was separated and washed with water (10 mL), saturated NaCl (10 mL), dried over MgSO4 and then concentrated in vacuo. The crude title compound was obtained and used without further purification.

1. customquenched with saturated aqueous solution of Na2CO3 (10 mL)
2. customThe organic phase was separated
3. washwashed with water (10 mL), saturated NaCl (10 mL)
4. dry with materialdried over MgSO4
5. concentrationconcentrated in vacuo