Trifluoroacetic acid → HCID 18072498, compound

HRID 552139Notes

Reaction equation

HRID 552139 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([C:14](=[O:26])[NH:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=2[C:22]([F:25])([F:24])[F:23])[CH2:10][CH2:9]1)=O)(C)(C)C.FC(F)(F)C(O)=O>ClCCl>[F:25][C:22]([F:23])([F:24])[C:17]1[CH:18]=[CH:19][CH:20]=[CH:21][C:16]=1[NH:15][C:14]([CH:11]1[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1)=[O:26]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 67172280HCID 67172280, compound

Product 1

HCID 18072498HCID 18072498, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a stirred solution of 4-(2-trifluoromethylphenylcarbamoyl)piperidine-1-carboxylic acid tert-butyl ester (0.450 g, 1.20 mmol) in dichloromethane (10 mL) was added trifluoroacetic acid (1.4 mL). The resulting mixture was stirred at ambient temperature for 16 hours and then quenched with saturated aqueous solution of Na2CO3 (10 mL). The organic phase was separated and washed with water (10 mL), saturated NaCl (10 mL), dried over MgSO4 and then concentrated in vacuo. The crude title compound was obtained and used without further purification.

Workup

  1. customquenched with saturated aqueous solution of Na2CO3 (10 mL)
  2. customThe organic phase was separated
  3. washwashed with water (10 mL), saturated NaCl (10 mL)
  4. dry with materialdried over MgSO4
  5. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-41507405c95946659e74f6765773ee0e
Source dataset
uspto-grants-2011_05
Patent number
US07951805B2

Reaction notes

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