反应详情

To a stirred solution of 4-methyl-4-(2-trifluoromethylphenoxy)piperidine-1-carboxylic acid tert-butyl ester (0.025 g, 0.070 mmol) in dichloromethane (5 mL) was added trifluoroacetic acid (1 mL). The resulting mixture was stirred at ambient temperature for 24 hours and then quenched with saturated aqueous solution of Na2CO3 (5 mL). The organic phase was washed with water (10 mL), saturated NaCl (10 mL), dried over MgSO4 and then concentrated in vacuo. The crude title compound was obtained and used without further purification.

1. customquenched with saturated aqueous solution of Na2CO3 (5 mL)
2. washThe organic phase was washed with water (10 mL), saturated NaCl (10 mL)
3. dry with materialdried over MgSO4
4. concentrationconcentrated in vacuo