反应详情

To a solution of 4-(2-trifluoromethylbenzoyl)piperidine-1-carboxylic acid tert-butyl ester (0.812 g, 2.27 mmol) in dichloromethane (60 mL) was added trifluoroacetic acid (2 mL). The reaction mixture was stirred at ambient temperature overnight., then washed with saturated NaHCO3. The organic phase was separated, dried over MgSO4 and concentrated. The title compound was obtained in 55% yield (0.319 g) and used for next step reaction without further purification.

1. wash, then washed with saturated NaHCO3
2. customThe organic phase was separated
3. dry with materialdried over MgSO4
4. concentrationconcentrated