HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Methylnicotinic acid → N-(6-chloro-7-ethoxy-9H-beta-carbolin-8-yl)-2-methyl-nicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Methylnicotinic acid | HCID 643373 | — |
| Reactant | 6-chloro-7-ethoxy-9H-beta-carbolin-8-ylamine | HCID 67164452 | — |
| Product | N-(6-chloro-7-ethoxy-9H-beta-carbolin-8-yl)-2-methyl-nicotinamide | HCID 11440410 | 40% |
Reaction Steps
The desired compound was prepared according to Method A from 6-chloro-7-ethoxy-9H-β-carbolin-8-ylamine and 2-methylnicotinic acid in 40% yield. 1H-NMR (300 MHz, MeOH-d4): δ 1.39 (t, 3H), 2.76 (s, 3H), 4.14 (q, 2H), 7.43 (dd, 1H), 8.05 (d, 1H), 8.26 (m, 3H), 8.55 (d, 1H), 8.79 (s, 1H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07951801B2 |
| Source dataset | uspto-grants-2011_05 |
| ORD ID | ord-8c5a57bfaf9d4a0ea7f34c624488c752 |
| Source note | uspto-grants-2011_05 |