HRID552246

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID10009

3-Pyridinamine

C5H6N2

反应SMILES：CC1(C)CN(CC(=O)O)[C@H](C(=O)Nc2cc(Cl)cc3c2[nH]c2cnccc23)CO1

HCID11384512

(5S)-5-[[(6-Chloro-9H-pyrido[3,4-b]indol-8-yl)amino]carbonyl]-2,2-dimethyl-4-morpholineacetic acid

C20H21ClN4O4

PRODUCTS

产物

反应SMILES：CC1(C)CN(CC(=O)Nc2cccnc2)[C@H](C(=O)Nc2cc(Cl)cc3c2[nH]c2cnccc23)CO1

HCID11691710

未命名化合物

收率 55%

PROCEDURE

实验过程

The desired compound was prepared according to Method F from [(S)-5-(6-Chloro-9H-beta-carbolin-8-ylcarbamoyl)-2,2-dimethyl-morpholin-4-yl]-acetic acid and 3-aminopyridine. The product was isolated as hydrochloride salt in 55% yield. 1HNMR (300 MHz, D2O): δ 1.34 (s, 3H), 1.54 (s, 3H), 2.60 (d,1H), 3.4 (d, 1H), 3.50 (d, 1H), 3.70 (t, 1H), 3.81 (d, 1H) 4.23 (d, 2H), 7.69 (d, 1H), 7.98 (d, 1H), 8.01 (d, 1H), 8.17(d, 1H), 8.42 (d, 1H), 8.48-8.55 (m, 3H), 9.09 (s,1H), 9.30 (d, 1H). Retention Time (LC, method: ammonium acetate standard): 1.56 min. MS (M+H+): 493.2.